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Hello,

I did more tests as you suggested. I actually ended up removing all the plugins from the track except for the main instrument itself. However, that did not make any difference.

I've attached a screenshot that shows the MIDI and the mixed-down Audio - you can see that the 3rd beat starts a little later than the first 2 beats.

So removing the Calf plugin(s) did not make any difference here. This was done with Frames/period set to 2048 (46.4 msec).
If I change it to Frames/Period 512 (11.6 msec), it will sound normal.

Thanks!